Maria Piazuelo

BACKGROUND: Tools predicting incident esophageal adenocarcinoma (EAC) and gastric cardia adenocarcinoma (GCA) that can be automated in electronic health records (EHRs) to guide screening decisions are needed…

INTRODUCTION. Our previous study reported a significant increase in metachronous recurrence of early gastric cancer after endoscopic submucosal dissection due to CD44v9-positive cancer stem-like cells in _H. pylori_-infected stomach tissue (_BR. J. CANCER_ 109:379, 2013)…

BACKGROUND: Aspirin has been known for its chemopreventive effect against various cancers. Evidence for the chemopreventive effect of the very long-term use of aspirin is still uncertain…

BACKGROUND: Perianal fistulae are highly morbid complications of Crohn’s disease (CD) with a cumulative incidence of 20-25%; despite demonstrated efficacy of infliximab treatment, estimates of complete resolution are only 20-30%. Ultimately, 20% of patients will require proctectomy…

Gastric cancer is the 4th leading cause of cancer deaths worldwide. _Helicobacter pylori _infection is the primary risk factor for gastric cancer. In the United States, gastric cancer rates have been declining for several decades, likely due to reduced _H. pylori _infection rates…

_Helicobacter pylori_ is the strongest risk factor for gastric cancer; however, only a minority of infected individuals develop disease. One microbial cancer-linked locus is the _cag_ type 4 secretion system (_cag_T4SS), which translocates the oncoprotein CagA into host cells…

_Helicobacter pylori _is the strongest known risk factor for gastric cancer, and pathologic outcomes are mediated via complex interactions among _H. pylori _virulence factors, host immune responses, and the exposome…

INTRODUCTION: Dysregulated polyamine metabolism during _Helicobacter pylori_ infection can lead to the development of gastric cancer. The polyamine spermine is back-converted to spermidine by spermine oxidase (SMOX). We have shown that _H…

INTRODUCTION: The enzyme deoxyhypusine synthase (DHPS) conjugates the N-terminal moiety of the polyamine spermidine to the lysine-50 residue of eukaryotic translation initiation factor 5A (EIF5A) to form a unique amino acid, hypusine…

BACKGROUND. Gastric adenocarcinoma (GAC) is the third leading global cause of cancer mortality and the leading infection-associated cancer. In the U.S., GAC represents a major cancer disparity, with incidence rates 2-3X in non-white populations…