Alberto Delgado
Appearances
- DateMay 8, 2023BACKGROUND: Tools predicting incident esophageal adenocarcinoma (EAC) and gastric cardia adenocarcinoma (GCA) that can be automated in electronic health records (EHRs) to guide screening decisions are needed…
- DateMay 6, 2023INTRODUCTION. Our previous study reported a significant increase in metachronous recurrence of early gastric cancer after endoscopic submucosal dissection due to CD44v9-positive cancer stem-like cells in _H. pylori_-infected stomach tissue (_BR. J. CANCER_ 109:379, 2013)…
Presenter
Vanderbilt University Medical CenterSpeakers
Vanderbilt University Medical Center - DateMay 8, 2023BACKGROUND: Aspirin has been known for its chemopreventive effect against various cancers. Evidence for the chemopreventive effect of the very long-term use of aspirin is still uncertain…
- DateMay 6, 2023BACKGROUND: Perianal fistulae are highly morbid complications of Crohn’s disease (CD) with a cumulative incidence of 20-25%; despite demonstrated efficacy of infliximab treatment, estimates of complete resolution are only 20-30%. Ultimately, 20% of patients will require proctectomy…
Presenter
Speakers
Vanderbilt University Medical Center - DateMay 18, 2024_Helicobacter pylori_ is the strongest risk factor for gastric cancer; however, only a minority of infected individuals develop disease. One microbial cancer-linked locus is the _cag_ type 4 secretion system (_cag_T4SS), which translocates the oncoprotein CagA into host cells…
Presenter
Speakers
Vanderbilt University Medical CenterVanderbilt University Medical Center - DateMay 18, 2024INTRODUCTION: Dysregulated polyamine metabolism during _Helicobacter pylori_ infection can lead to the development of gastric cancer. The polyamine spermine is back-converted to spermidine by spermine oxidase (SMOX). We have shown that _H…
- DateMay 20, 2024INTRODUCTION: The enzyme deoxyhypusine synthase (DHPS) conjugates the N-terminal moiety of the polyamine spermidine to the lysine-50 residue of eukaryotic translation initiation factor 5A (EIF5A) to form a unique amino acid, hypusine…