Arthur Beyder

BACKGROUND: Enterochromaffin cells (ECs) are specialized gastrointestinal (GI) epithelial cells that transduce luminal forces and chemicals into release of signal molecules including serotonin (5-HT) to alter GI function including mucosal ion transport…

BACKGROUND AND AIMS: Peptostreptococcus stomatis (_P. stomatis_) is an enriched bacterium in colorectal cancer (CRC) patients as compared to healthy subjects in multiple cohorts. However, the potential role of _P. stomatis_ in colorectal tumorigenesis remains obscure…

Electrogastrography (EGG) non-invasively evaluates gastric motility but is widely viewed as lacking clinical utility…

This session will focus on intercellular signaling mechanisms between neurons and non-neuronal cells that control gut motor functions…

Background: Postoperative ileus (POI) is a common consequence of abdominal surgery and a neuroinflammation-based disorder of the gastrointestinal tract, which results in motility disturbances compromising patients' recovery…

The wiring of the enteric nervous system (ENS) is a dynamic process throughout development and adulthood. In the embryo, enteric neural crest derived cells expand and differentiate into the glia and neurons that form the ENS…

Paneth cells reside at the bottom of the crypts in the small intestine and are crucial for maintaining homeostasis of the epithelium by engendering host protection from enteric pathogens…

BACKGROUND: Intrinsic primary afferent neurons (IPANs) of the gastrointestinal (GI) tract respond to luminal content including pressure to initiate motor reflexes. Advillin is a marker of mouse IPANs and Avil-CreERT2 mice can drive the expression of optogenetic ion channels…

BACKGROUND: Muscularis macrophages (MMs) reside in the gut muscularis propria. A population of MMs share a phenotype with microglia and produce a large amount of Complement component 1qA (C1qa)…

BACKGROUND: Gastrointestinal (GI) motility disorders, such as chronic constipation, dysphagia, and fecal impaction, are more common in the elderly. In the vascular system, increased tissue stiffness with age is associated with a decline in contractile function of smooth muscle cells (SMCs)…

BACKGROUND The gastrointestinal tract (GI) has a sense of _gut touch_ by which low threshold mechanical inputs activate mechanoreceptors similar to Merkel cells that mediate skin touch…

This session will discuss the mechanisms of visceral hypersensitive in IBS and IBD focusing on specific microbiota and microbial products. The role of sex in sensory neuron excitability will be outlined. Novel ways to measure visceral hypersensitivity will also be presented…