Gianluca Cipriani

Phosphatase and tensin homolog (PTEN) is a lipid phosphatase, while its protein phosphatase activity is being suggested. Since the classical role of PTEN as a tumor suppressor is unclear in the gut, we hypothesize PTEN’s alternative function in regulating gut homeostasis…

BACKGROUND: Gastrointestinal (GI) motility disorders, such as chronic constipation, dysphagia, and fecal impaction, are more common in the elderly. In the vascular system, increased tissue stiffness with age is associated with a decline in contractile function of smooth muscle cells (SMCs)…

This session will discuss the effects of aging on muscularis macrophages and impact on gastrointestinal motility. The effect of pathogens on the sympathetic nervous system and changes in the brain in Celiac disease will be outlined…