Kristen Smith-Edwards

BACKGROUND AND AIMS: Peptostreptococcus stomatis (_P. stomatis_) is an enriched bacterium in colorectal cancer (CRC) patients as compared to healthy subjects in multiple cohorts. However, the potential role of _P. stomatis_ in colorectal tumorigenesis remains obscure…

SOCIETY: AGA

The wiring of the enteric nervous system (ENS) is a dynamic process throughout development and adulthood. In the embryo, enteric neural crest derived cells expand and differentiate into the glia and neurons that form the ENS…

This session will focus on intercellular signaling mechanisms between neurons and non-neuronal cells that control gut motor functions…

C1QA MUSCULARIS MACROPHAGES: A DYNAMIC PLAYER IN THE REGULATION OF SYNAPTIC FUNCTION AND EXPRESSION

A hallmark symptom of inflammatory bowel disease is abnormal colon motility, largely attributed to changes in enteric nervous system (ENS) function, but studies of dysmotility are based on models of ENS-driven peristalsis in distal colon regions…

BACKGROUND: Interstitial cells of Cajal (ICC), electrically active cells found throughout the gastrointestinal tract, generate spontaneous electrical slow waves, and transmit these waves to smooth muscle cells in the gut to produce phasic contractions…

This session will showcase novel methods to assess the ENS as well as optogenic manipulation of specific primary afferent neurons. Neurochemical changes in Hirschspruings disease will be discussed. Novel methods of studying the ENS with human organoids will be presented…