Sp590
ENTEROCHROMAFFIN CELLS IN FUNCTIONAL GASTROINTESTINAL DISEASES
Date
May 19, 2024
Presenter
Mayo Clinic-Rochester
Tracks
Related Products
MECHANICAL AND OPTOGENETIC STIMULATION OF INTRINSIC PRIMARY AFFERENT NEURONS OF THE MOUSE INTESTINES TRIGGERS SPECIFIC MOTOR PATTERNS
BACKGROUND: Intrinsic primary afferent neurons (IPANs) of the gastrointestinal (GI) tract respond to luminal content including pressure to initiate motor reflexes. Advillin is a marker of mouse IPANs and Avil-CreERT2 mice can drive the expression of optogenetic ion channels…
C1QA MUSCULARIS MACROPHAGES: A DYNAMIC PLAYER IN THE REGULATION OF SYNAPTIC FUNCTION AND EXPRESSION
BACKGROUND: Muscularis macrophages (MMs) reside in the gut muscularis propria. A population of MMs share a phenotype with microglia and produce a large amount of Complement component 1qA (C1qa)…
MECHANOGATED ION CHANNEL PIEZO2 TETHERS TO THE ACTOMYOSIN CYTOSKELETON IN INTESTINAL EPITHELIAL MECHANORECEPTORS
BACKGROUND The gastrointestinal tract (GI) has a sense of _gut touch_ by which low threshold mechanical inputs activate mechanoreceptors similar to Merkel cells that mediate skin touch…
INCREASED TISSUE STIFFNESS WITH AGE ALTERS DISTAL COLON SMOOTH MUSCLE CONTRACTILITY
BACKGROUND: Gastrointestinal (GI) motility disorders, such as chronic constipation, dysphagia, and fecal impaction, are more common in the elderly. In the vascular system, increased tissue stiffness with age is associated with a decline in contractile function of smooth muscle cells (SMCs)…
