Ryan Ungaro

Aconitate decarboxylase 1 (ACOD1; also known as IRG-1) is the ubiquitous source of the metabolite itaconate, which dampens inflammasome activation by preventing HIF1α production of IL-1β and prevents TNF production through NRF2 activation…

Handout [https://ddw.digitellinc…

BACKGROUND: Anti-granulocyte macrophage-colony stimulating factor autoantibodies (anti-GM-CSF) have been associated with development of Crohn’s disease (CD) and complications at time of diagnosis. There are limited data on anti-GM-CSF as a prognostic biomarker in CD…

BACKGROUND: Prevention of postoperative recurrence (POR) in Crohn’s disease (CD) after ileo-colonic (IC) resection is still a highly debated topic. Prophylactic immunosuppression after surgery is currently recommended in presence of at least one clinical risk factor (RF)…

Crohn’s disease (CD) is characterized by an aberrant microbiome composition – including a depletion of gut bacteria that produce short chain fatty acids (SCFA) – and by presence of anti-commensal systemic IgG…

BACKGROUND: The Montreal Classification (MC) captures the heterogeneity of Crohn's disease (CD). While the MC is an important tool for characterizing CD, its ascertainment for real-world studies requires manual chart review that is labor-intensive with limited scalability…

Anti-granulocyte/macrophage-colony stimulating factor autoantibody (GM-CSF AuAB) has been identified before the onset of Crohn’s Disease (CD) and is associated with an increase in complicated disease. However, its connection to the gut microbiome, a key factor in CD progression, remains unclear…

BACKGROUND: Crohn's disease (CD) can lead to progressive bowel damage and disability. Disability has been proposed by the SPIRIT-IOIBD consensus as an endpoint in disease-modification trials. Despite this, there is scarce data on disability at CD diagnosis…

Approximately 20-30% of individuals with Crohn's disease (CD) experience a relatively mild disease course without progression. However, there is no widely accepted objective definition of mild CD. We aimed to identify endoscopic severity cut-offs that can be used to define mild non-progressive CD…

Approximately 20% of patients with Crohn’s disease (CD) have perianal fistulizing CD, which are most often complex perianal fistula (PAF). Studies have shown that 4-5% of patients with CD present with PAF without luminal disease, termed isolated perianal CD (iPCD)…

Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) maintains mononuclear phagocytes (MNP) and supports intestinal immune homeostasis. Anti-GM-CSF autoantibodies (aGMAbs) are found in approx. 25% of all Crohn’s disease (CD) patients…