Lee Denson

A key feature in intestinal immunity is the dynamic intestinal barrier, which separates the host from resident and pathogenic microbiota through a mucus gel impregnated with antimicrobial peptides…

BACKGROUND: Tumor necrosis factor inhibitors (TNFi) are a mainstay of pediatric Crohn’s disease (PCD) therapy; yet not all patients respond, and others lose response over time. Combination therapy with methotrexate may improve response; however, this has not been rigorously evaluated…

BACKGROUND: The low fermentable oligosaccharide, disaccharide, monosaccharide, and polyol (FODMAP) diet, which restricts FODMAP intake, currently is used as a treatment for pain-related disorders of gut-brain interaction (DGBI)…

Perturbations in the gut mucosal immune response contributes to IBD. Non-immune cell popopulations including epithelial and stromal cells also play an important role in intestinal inflammation…

SOCIETY: AGA With the expansion of IBD treatment options, there is increasingly the need for predictive models to determine which treatments work best for which patients with IBD…

BACKGROUND: Given the variable response to anti-TNF therapy in patients with Crohn’s disease (CD), we hypothesized there is a core biologic (inflammatory) signature associated with early response and endoscopic healing (EH)…

BACKGROUND: Prior pharmacokinetic (PK) investigations have identified an association between anti-TNF trough concentrations (cTrough) and clinical or biochemical remission for children with Crohn’s Disease (CD)…

INTRODUCTION: Missense mutations in the epithelial NADPH oxidase DUOX2 are associated with strictures in children with Crohn’s Disease (CD)…

To date, genome-wide association studies (GWAS) have identified 418 independent genetic risk loci contributing to inflammatory bowel disease (IBD) and its two subtypes: ulcerative colitis (UC) and Crohn’s disease (CD) (PMID:37156999)…

Anti-granulocyte/macrophage-colony stimulating factor autoantibody (GM-CSF AuAB) has been identified before the onset of Crohn’s Disease (CD) and is associated with an increase in complicated disease. However, its connection to the gut microbiome, a key factor in CD progression, remains unclear…

ABSTRACT: BACKGROUND/OBJECTIVES: Acute pancreatitis (AP) is increasingly recognized as a risk factor for diabetes mellitus (DM) even after a single episode of AP. Observational studies in childhood AP are lacking but represent the ideal forum to develop risk models…

SOCIETY: AGA

This session focuses on the role of immune cells in intestinal inflammation, discussing mast-cell wtih epithelial interactions, a novel way to transfect and analyze human monocytes and the function of different T cell populations…