Lee Denson
Cincinnati Children’s Hospital Medical Center
Appearances
- DateMay 8, 2023A key feature in intestinal immunity is the dynamic intestinal barrier, which separates the host from resident and pathogenic microbiota through a mucus gel impregnated with antimicrobial peptides…
Presenter
Cincinnati Children’s Hospital Medical Center - DateMay 8, 2023BACKGROUND: Tumor necrosis factor inhibitors (TNFi) are a mainstay of pediatric Crohn’s disease (PCD) therapy; yet not all patients respond, and others lose response over time. Combination therapy with methotrexate may improve response; however, this has not been rigorously evaluated…
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Cincinnati Children’s Hospital Medical CenterCincinnati Children's Hospital Medical Center - DateMay 8, 2023BACKGROUND: The low fermentable oligosaccharide, disaccharide, monosaccharide, and polyol (FODMAP) diet, which restricts FODMAP intake, currently is used as a treatment for pain-related disorders of gut-brain interaction (DGBI)…
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- DateMay 9, 2023Perturbations in the gut mucosal immune response contributes to IBD. Non-immune cell popopulations including epithelial and stromal cells also play an important role in intestinal inflammation…
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Cedars-Sinai Medical CenterCincinnati Children’s Hospital Medical Center - DateMay 18, 2024SOCIETY: AGA With the expansion of IBD treatment options, there is increasingly the need for predictive models to determine which treatments work best for which patients with IBD…
Moderators
Cincinnati Children’s Hospital Medical CenterCedars-Sinai Medical CenterSpeakers
Katholieke Universiteit Leuven Universitaire Ziekenhuizen LeuvenNorthwestern University Feinberg School of MedicineUniversity Hospitals Leuven - DateMay 20, 2024BACKGROUND: Given the variable response to anti-TNF therapy in patients with Crohn’s disease (CD), we hypothesized there is a core biologic (inflammatory) signature associated with early response and endoscopic healing (EH)…
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Cincinnati Children’s Hospital Medical Center - DateMay 21, 2024BACKGROUND: Prior pharmacokinetic (PK) investigations have identified an association between anti-TNF trough concentrations (cTrough) and clinical or biochemical remission for children with Crohn’s Disease (CD)…
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Cincinnati Children’s Hospital Medical Center - DateMay 20, 2024INTRODUCTION: Missense mutations in the epithelial NADPH oxidase DUOX2 are associated with strictures in children with Crohn’s Disease (CD)…
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Cincinnati Children's Hospital Medical CenterCincinnati Children’s Hospital Medical Center - DateMay 18, 2024To date, genome-wide association studies (GWAS) have identified 418 independent genetic risk loci contributing to inflammatory bowel disease (IBD) and its two subtypes: ulcerative colitis (UC) and Crohn’s disease (CD) (PMID:37156999)…
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Cincinnati Children's Hospital Medical CenterCincinnati Children's Hospital Medical CenterCincinnati Children's Hospital Medical CenterCincinnati Children’s Hospital Medical Center - DateMay 19, 2024Anti-granulocyte/macrophage-colony stimulating factor autoantibody (GM-CSF AuAB) has been identified before the onset of Crohn’s Disease (CD) and is associated with an increase in complicated disease. However, its connection to the gut microbiome, a key factor in CD progression, remains unclear…
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Emory UniversityCincinnati Children’s Hospital Medical CenterIcahn School of Medicine at Mount Sinai - DateMay 19, 2024ABSTRACT: BACKGROUND/OBJECTIVES: Acute pancreatitis (AP) is increasingly recognized as a risk factor for diabetes mellitus (DM) even after a single episode of AP. Observational studies in childhood AP are lacking but represent the ideal forum to develop risk models…
Presenter
Cincinnati CHildren's Hospital and Medical CenterSpeakers
University of MinnesotaCincinnati Children’s Hospital Medical Center - DateMay 4, 2025SOCIETY: AGA
Moderators
Icahn School of Medicine at Mount Sinai Department of PediatricsCincinnati Children’s Hospital Medical Center - DateMay 4, 2025This session focuses on the role of immune cells in intestinal inflammation, discussing mast-cell wtih epithelial interactions, a novel way to transfect and analyze human monocytes and the function of different T cell populations…
Moderators
Cleveland ClinicCincinnati Children’s Hospital Medical Center