Jefferson Vallance

INTRODUCTION: Missense mutations in the epithelial NADPH oxidase DUOX2 are associated with strictures in children with Crohn’s Disease (CD)…

BACKGROUND: Proper formation and maturation of the intestinal brush border is critical for adequate digestion, nutrition, and host defense. Mature brush borders feature specific localization of several proteins involved in actin bundling (e.g., Vil1, Eps8, Misp), plasma membrane cross-linking (e.g…