Joseph Murray

Aconitate decarboxylase 1 (ACOD1; also known as IRG-1) is the ubiquitous source of the metabolite itaconate, which dampens inflammasome activation by preventing HIF1α production of IL-1β and prevents TNF production through NRF2 activation…

BACKGROUND: Contamination-free oats are considered safe for most patients with celiac disease (CeD)…

INTRODUCTION Interleukin-15 (IL-15) is an important cytokine involved in tissue homeostasis and inflammation, and a potent regulator of innate and adaptive immune responses…

BACKGROUND AND AIM: Intestinal epithelial cells (IECs) are emerging as potential regulators of CD4+ T cell responses through MHC class II expression. However, their role as antigen-presenting cells and in the activation of gluten-reactive CD4+ T cells has never been proven…