Over the past decade, big data and artificial intelligence (AI) have become standard concepts in digestive disease research, both as individual tools and applied together…
The burden of IBD is rising globally. This session aims to understand the role of genetics in the development of IBD in diverse populations and define the pre-disease state in IBD. It will also explore the emerging field of multi-omics to clinically characterize IBD…
BACKGROUND: Perianal fistulae are highly morbid complications of Crohn’s disease (CD) with a cumulative incidence of 20-25%; despite demonstrated efficacy of infliximab treatment, estimates of complete resolution are only 20-30%. Ultimately, 20% of patients will require proctectomy…
BACKGROUND: PSC is a chronic inflammatory condition of the biliary epithelium characterized by concentric periductal fibrosis. As opposed to inflammatory bowel disease (IBD), a frequently overlapping trait, there are currently no drugs that definitively slow disease progression…
BACKGROUND: The Montreal Classification (MC) captures the heterogeneity of Crohn's disease (CD). While the MC is an important tool for characterizing CD, its ascertainment for real-world studies requires manual chart review that is labor-intensive with limited scalability…
BACKGROUND: Although incidence of Inflammatory Bowel Disease (IBD) is rising in underrepresented populations, including Hispanics, genetic studies of IBD have primarily focused on Northern European ancestral populations…
Background: The genetic contribution to inflammatory bowel disease (IBD) spans monogenic and polygenic forms. Monogenic variants with moderate to high penetrance are enriched in individuals with very early onset IBD who present before 6 years of age…
Autologous stem cell transplant (auto-SCT) is unparalleled in its ability to induce clinical and endoscopic remission for the treatment of refractory Crohn’s disease (CD)…