Mark Riddle

Aconitate decarboxylase 1 (ACOD1; also known as IRG-1) is the ubiquitous source of the metabolite itaconate, which dampens inflammasome activation by preventing HIF1α production of IL-1β and prevents TNF production through NRF2 activation…

Crohn’s disease (CD) is characterized by an aberrant microbiome composition – including a depletion of gut bacteria that produce short chain fatty acids (SCFA) – and by presence of anti-commensal systemic IgG…