Jianwen Que

Background: Eosinophilic Esophagitis (EoE) is one of the most predominant causes of chronic esophageal symptoms in children. Pathological changes of the esophageal epithelium in EoE are characterized by basal cell hyperplasia (BCH), infiltration of eosinophils and elevated levels of cytokines (e.g…

BACKGROUND: Barrett’s Esophagus (BE) develops after reflux-mediated injury to distal esophagus and is only known precursor of esophageal adenocarcinoma (EAC), a highly deadly and increasingly prevalent cancer…

The speakers in this session will provide insights into diverse molecular mechanisms of metaplasia, dysplasia and neoplasia across the esophagus, stomach, and colon…

INTRODUCTION: Eosinophilic esophagitis (EoE) is an inflammatory disorder characterized by esophageal eosinophilia, basal cell hyperplasia (BCH), and epithelial barrier dysfunction promoted by inflammatory cytokines, including interleukin (IL)-13…

BACKGROUND: The incidence of esophageal adenocarcinoma (EAC) is rapidly increasing in Western countries. Most EACs originate from Barrett’s esophagus (BE), a precancerous lesion initiated by chronic reflux of gastrointestinal contents, especially acidic bile salts (ABS)…

BACKGROUND: The most common risk factor for esophageal adenocarcinoma is gastroesophageal reflux disease (GERD), a digestive disorder that affects 20% of adults in North America…