Zheng Chen

BACKGROUND: Barrett’s Esophagus (BE) develops after reflux-mediated injury to distal esophagus and is only known precursor of esophageal adenocarcinoma (EAC), a highly deadly and increasingly prevalent cancer…

BACKGROUND: Gut microbiota composition and diversity have been shown to influence the effectiveness of cancer immunotherapies…

Colorectal cancer (CRC) remains a leading cause of cancer related mortality worldwide…

BACKGROUND: Gastric cancer (GC) is the fourth most common cause of cancer-related death worldwide. GC has a dismal 5-year survival rate of about 32%, decreasing to 5% for stage IV diagnoses. Helicobacter pylori (H. pylori) infection is the strongest risk factor for gastric carcinogenesis…

BACKGROUND: _Helicobacter pylori _infection is the main risk factor for gastric cancer. Fibroblast growth factor receptor 4 is a member of transmembrane tyrosine kinase receptors that are activated in cancer…

BACKGROUND: The incidence of esophageal adenocarcinoma (EAC) is rapidly increasing in Western countries. Most EACs originate from Barrett’s esophagus (BE), a precancerous lesion initiated by chronic reflux of gastrointestinal contents, especially acidic bile salts (ABS)…