Curtis Huttenhower

BACKGROUND: Marine omega-3 fatty acids (MO3FAs) - which include eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) - are fatty acids that have anti-inflammatory properties, reducing C-reactive protein (CRP) and proinflammatory cytokines…

BACKGROUND The gut microbiome is central to Crohn’s disease (CD) pathogenesis but the relative contribution of different environmental factors to disease compositional variation is unknown…

BACKGROUND: Non-alcoholic steatohepatitis (NASH), a leading cause of liver-related morbidity and mortality, is highly prevalent in people living with HIV (PLWH).1 Microbial translocation (MT) associated with hepatic inflammation and fibrosis may play a critical role in NASH pathogenesis…

The microbiome plays a central role in intestinal inflammation in IBD. It is influenced by environmental factors included diet…

The microbiome plays a central role in intestinal inflammation in IBD. It is influenced by environmental factors included diet…

BACKGROUND AND AIMS: Chemoresistance is a major cause of colorectal cancer (CRC) recurrence and death. The critical role of gut microbiome in the efficacy of CRC chemotherapy remains unclear…

BACKGROUND: Diet is known to alter the risk of depression. Increasing data also demonstrate a causal role of the gut microbiome in mental illness, via the gut-brain axis. However, it remains unclear how diet and the microbiome mechanistically influence depression risk in humans…

We and others have demonstrated a tight coupling between dietary intake, gut microbial ecology, and near-term alterations in cardiometabolic biomarkers in the ZOE PREDICT-1 study (Zeevi 2015; Asnicar & Berry 2021)…

We and others have demonstrated a tight coupling between dietary intake, gut microbial ecology, and near-term alterations in cardiometabolic biomarkers in the ZOE PREDICT-1 study (Zeevi 2015; Asnicar & Berry 2021)…

BACKGROUND: Through shotgun metagenomic sequencing, we identified the depletion of probiotic species_ Lactobacillus acidophilus_ in stools of mice with non-alcoholic fatty liver disease-associated hepatocellular carcinoma (NAFLD-HCC)…

Colorectal cancer (CRC) remains a leading cause of cancer related mortality worldwide…

BACKGROUND Growing evidence links high ultra-processed food (UPF) intake to various diseases, including colorectal cancer (CRC). However, the metabolomic changes underlying this relationship remain unknown…

BACKGROUND: Proton pump inhibitor (PPI) use has been linked to alterations in gut microbial communities, but prior studies have been limited to describing broad differences in microbial abundance…

BACKGROUND: Primary bile acids (PBA) and their gut microbial metabolites (secondary BA [SBA]) modulate immune function and can contribute to intestinal inflammation and tumorigenesis. Diet alters the production and metabolism of BAs…

Metabolic dysfunction-associated steatotic liver disease (MASLD) is highly prevalent and a leading cause of liver-related morbidity and mortality…

BACKGROUND: Coupled with well-characterized host genetic susceptibilities and environmental risk factors, alterations of gut microbial communities contribute to risk and severity of the inflammatory bowel diseases (IBD) and their subtypes, Crohn’s disease (CD) and ulcerative colitis (UC)…

BACKGROUND: Diet and the gut microbiome are both established modulators of inflammation. However, their combined effect in shaping systemic inflammation remains unknown…

INTRODUCTION: Controversies about the long-term health consequences of low-carbohydrate diets (LCD) persist…

BACKGROUND: The gut microbiome is increasingly recognized as an important factor modulating intestinal inflammation, tumorigenesis, and immunological functions…