Edward Giovannucci

BACKGROUND: Aspirin has been known for its chemopreventive effect against various cancers. Evidence for the chemopreventive effect of the very long-term use of aspirin is still uncertain…

BACKGROUND AND AIMS: Chemoresistance is a major cause of colorectal cancer (CRC) recurrence and death. The critical role of gut microbiome in the efficacy of CRC chemotherapy remains unclear…

BACKGROUND: Diets high in animal fat and low in plant fiber increase colorectal cancer (CRC) risk, while diets high in fiber, but low in animal fat, are protective. Bacteria present in the colon produce beneficial and harmful metabolites from our diets…

BACKGROUND: We derived a polygenic risk score (PRS) for diverticulitis based on known susceptibility loci for diverticular disease and investigated its joint association with body mass index (BMI), a risk factor for diverticulitis…

BACKGROUND: The detrimental impact of diverticulitis on quality of life and health care expenditures, particularly among those with recurrent episodes is substantial…

BACKGROUND: The gut microbiome is increasingly recognized as an important factor modulating intestinal inflammation, tumorigenesis, and immunological functions…