Andrew Chan

This annual session will provide DDW attendees the opportunity to hear opposing viewpoints from leading GI experts on the most challenging issues in clinical gastroenterology and hepatology, in a debate format…

BACKGROUND: Marine omega-3 fatty acids (MO3FAs) - which include eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) - are fatty acids that have anti-inflammatory properties, reducing C-reactive protein (CRP) and proinflammatory cytokines…

SOCIETY: AGA

BACKGROUND: Aspirin has been known for its chemopreventive effect against various cancers. Evidence for the chemopreventive effect of the very long-term use of aspirin is still uncertain…

BACKGROUND The gut microbiome is central to Crohn’s disease (CD) pathogenesis but the relative contribution of different environmental factors to disease compositional variation is unknown…

BACKGROUND The gut microbiome is central to Crohn’s disease (CD) pathogenesis but the relative contribution of different environmental factors to disease compositional variation is unknown…

The microbiome plays a central role in intestinal inflammation in IBD. It is influenced by environmental factors included diet…

The microbiome plays a central role in intestinal inflammation in IBD. It is influenced by environmental factors included diet…

BACKGROUND AND AIMS: Chemoresistance is a major cause of colorectal cancer (CRC) recurrence and death. The critical role of gut microbiome in the efficacy of CRC chemotherapy remains unclear…

BACKGROUND: Diet is known to alter the risk of depression. Increasing data also demonstrate a causal role of the gut microbiome in mental illness, via the gut-brain axis. However, it remains unclear how diet and the microbiome mechanistically influence depression risk in humans…

We and others have demonstrated a tight coupling between dietary intake, gut microbial ecology, and near-term alterations in cardiometabolic biomarkers in the ZOE PREDICT-1 study (Zeevi 2015; Asnicar & Berry 2021)…

We and others have demonstrated a tight coupling between dietary intake, gut microbial ecology, and near-term alterations in cardiometabolic biomarkers in the ZOE PREDICT-1 study (Zeevi 2015; Asnicar & Berry 2021)…

BACKGROUND: Through shotgun metagenomic sequencing, we identified the depletion of probiotic species_ Lactobacillus acidophilus_ in stools of mice with non-alcoholic fatty liver disease-associated hepatocellular carcinoma (NAFLD-HCC)…

Colorectal cancer (CRC) remains a leading cause of cancer related mortality worldwide…

BACKGROUND Growing evidence links high ultra-processed food (UPF) intake to various diseases, including colorectal cancer (CRC). However, the metabolomic changes underlying this relationship remain unknown…

BACKGROUND: Proton pump inhibitor (PPI) use has been linked to alterations in gut microbial communities, but prior studies have been limited to describing broad differences in microbial abundance…

BACKGROUND: Primary bile acids (PBA) and their gut microbial metabolites (secondary BA [SBA]) modulate immune function and can contribute to intestinal inflammation and tumorigenesis. Diet alters the production and metabolism of BAs…

BACKGROUND: The long-term risk of colorectal cancer (CRC) incidence and mortality after negative colonoscopy screening (NCS) according to individuals’ risk profiles remains unknown…

Metabolic dysfunction-associated steatotic liver disease (MASLD) is highly prevalent and a leading cause of liver-related morbidity and mortality…

BACKGROUND: We derived a polygenic risk score (PRS) for diverticulitis based on known susceptibility loci for diverticular disease and investigated its joint association with body mass index (BMI), a risk factor for diverticulitis…

Gallstone disease is highly prevalent and costly in the USA: over 40 million people are affected with estimated annual health costs of $4 billion…

BACKGROUND: The detrimental impact of diverticulitis on quality of life and health care expenditures, particularly among those with recurrent episodes is substantial…

BACKGROUND: Coupled with well-characterized host genetic susceptibilities and environmental risk factors, alterations of gut microbial communities contribute to risk and severity of the inflammatory bowel diseases (IBD) and their subtypes, Crohn’s disease (CD) and ulcerative colitis (UC)…

BACKGROUND: Epidemiologic studies have identified numerous dietary and lifestyle risk factors for Crohn’s disease (CD). However, the causal relationship between these factors and CD is unknown. Randomized trials of lifestyle interventions are unlikely to be performed due to limited feasibility…

BACKGROUND: Increased dairy consumption has been linked to the development of chronic inflammatory disorders and autoimmune diseases. Little research has been done to explore the relationship between dairy consumption and risk of inflammatory bowel disease (IBD)…

BACKGROUND: Diet and the gut microbiome are both established modulators of inflammation. However, their combined effect in shaping systemic inflammation remains unknown…

INTRODUCTION: Emerging evidence has linked the gut microbiome to cognitive aging. Antibiotic use can rapidly reduce bacterial diversity and lead to dysbiosis that persists for months to years, potentially impairing cognitive function…

INTRODUCTION: Controversies about the long-term health consequences of low-carbohydrate diets (LCD) persist…

INTRODUCTION: The incidence of early-onset colorectal cancer (EOCRC) has been increasing worldwide over the last decade…

BACKGROUND: The gut microbiome is increasingly recognized as an important factor modulating intestinal inflammation, tumorigenesis, and immunological functions…

BACKGROUND: Several observational and randomized studies have found an association between aspirin use and lower risk of colorectal cancer (CRC) incidence and mortality…