Ashley Keehn

BACKGROUND: In irritable bowel syndrome (IBS), insufficient suppression of proteolytic activity (PA) leads to intestinal barrier disruption and visceral hypersensitivity. Our work shows host PA is suppressed by microbial β-glucuronidase (GUS) activity…

BACKGROUND: Approximately 15% of individuals develop post-infection irritable bowel syndrome (PI-IBS) after _Campylobacter_ infection. Our previous work shows 40% of PI-IBS patients have high fecal proteolytic activity (PA) and changes in microbiota composition…

INTRODUCTION: Alpha-Gal Syndrome (AGS) is an IgE-mediated allergic reaction to galactose-α-1,3-galactose (alpha-gal) induced by Lone Star tick bite with symptoms typically triggered by mammalian meat consumption…