Margaret Breen-Lyles

Appearances

DIETARY LACTONES CAUSE INCREASED INTESTINAL PROTEOLYTIC ACTIVITY IN HUMANIZED MOUSE MODEL OF IRRITABLE BOWEL SYNDROME THROUGH A LOSS OF MICROBIAL β-GLURONIDASE ACTIVITY
Date
May 21, 2024
BACKGROUND: In irritable bowel syndrome (IBS), insufficient suppression of proteolytic activity (PA) leads to intestinal barrier disruption and visceral hypersensitivity. Our work shows host PA is suppressed by microbial β-glucuronidase (GUS) activity…
Presenter
Adam Edwinson
Speakers
Jing Kong
Lu Yang
Amanda Blankenberger
Ruben Mars
Mayo Clinic
Lisa Till
Margaret Breen-Lyles
Ashley Keehn
Jun Chen
Gianrico Farrugia
Madhusudan Grover
Mayo Clinic
LONGITUDINAL ASSESSMENT OF MICROBIAL DIVERSITY FOLLOWING CAMPYLOBACTER INFECTION ASSOCIATES WITH PROTEOLYTIC ACTIVITY CHANGES IN POST-INFECTION IRRITABLE BOWEL SYNDROME
Date
May 18, 2024
BACKGROUND: Approximately 15% of individuals develop post-infection irritable bowel syndrome (PI-IBS) after _Campylobacter_ infection. Our previous work shows 40% of PI-IBS patients have high fecal proteolytic activity (PA) and changes in microbiota composition…
Presenter
Amanda Blankenberger
Speakers
Elvira Lesmana
Lu Yang
Adam Edwinson
Margaret Breen-Lyles
Ashley Keehn
Robin Patel
Jun Chen
Gianrico Farrugia
Madhusudan Grover
Mayo Clinic