Jun Chen

BACKGROUND: Long COVID (LC) affects approximately 10% of SARS-CoV-2 positive patients, causing significant workforce loss and an annual economic cost of $743 billion in the United States. Previous studies have suggested an association between long COVID and alterations in the gut microbiome…

BACKGROUND: In irritable bowel syndrome (IBS), insufficient suppression of proteolytic activity (PA) leads to intestinal barrier disruption and visceral hypersensitivity. Our work shows host PA is suppressed by microbial β-glucuronidase (GUS) activity…

BACKGROUND: Approximately 15% of individuals develop post-infection irritable bowel syndrome (PI-IBS) after _Campylobacter_ infection. Our previous work shows 40% of PI-IBS patients have high fecal proteolytic activity (PA) and changes in microbiota composition…