Tim Vanuytsel

Disorders of gut-brain interaction (DGBI), including irritable bowel syndrome (IBS) and functional dyspepsia (FD), are among the most common gastrointestinal (GI) disorders seen in primary care and GI practices. The pathophysiology is multifactorial and not well understood…

Disorders of gut-brain interaction (DGBI), including irritable bowel syndrome (IBS) and functional dyspepsia (FD), are among the most common gastrointestinal (GI) disorders seen in primary care and GI practices. The pathophysiology is multifactorial and not well understood…

BACKGROUND: Mesenteric fat is increasingly believed to exert an important influence on intestinal inflammation. A hallmark of severe Crohn's disease (CD) is the accumulation of mesenteric fat around the inflamed intestine, typically in the terminal ileum…

Ageing seems to have a beneficial effect on irritable bowel syndrome (IBS) (Sperber et al. Gastroenterology 2021), and the odds of developing IBS are lower when age is above 50 years (Lovell & Ford CGH 2012). Older age may also affect symptom reporting and quality of life…

Dysphagia and chest pain are the common symptoms in achalasia. The mechanisms underlying such symptoms are not completely understood. The two symptoms can be triggered by mechanical stimulation via the sensory vagal and spinal afferent nerve fibers…

Interleukin-15 (IL-15) is a cytokine involved in tissue homeostasis and inflammation, and a potent regulator of innate and adaptive immune responses. IL-15 expression has been shown to be dysregulated in celiac disease (CeD)…

BACKGROUND: Historically, functional dyspepsia (FD) has been subdivided into postprandial distress syndrome, PDS, with meal-related symptoms (i.e. early satiation or postprandial fullness) and epigastric pain syndrome, EPS, defined as meal-unrelated (i.e…

I: Functional dyspepsia (FD) is a chronic gastrointestinal (GI) disorder with incompletely understood pathophysiology…

Interleukin-15 (IL-15) is a cytokine involved in tissue homeostasis and inflammation, and a potent regulator of innate and adaptive immune responses. IL-15 expression has been shown to be dysregulated in eosinophilic esophagitis (EoE)…

Introduction: Physiological and psychological factors contribute to gastroesophageal reflux symptoms. However, most research assesses reflux symptom severity via questionnaires…

Our previous pilot study showed that treatment with the histamine 1 receptor antagonist ebastine improved symptoms in patients with irritable bowel syndrome (IBS)…

INTRODUCTION: Irritable bowel syndrome (IBS) is a common disorder of gut-brain interaction characterized by abdominal pain associated with bowel movements. Local allergic reactions have been implicated as a mechanism underlying the food-related symptoms often reported by IBS patients…

Opioid-induced constipation (OIC) is a highly prevalent condition among patients treated with opioids for chronic pain…