Guy Boeckxstaens

Our previous pilot study showed that treatment with the histamine 1 receptor antagonist ebastine improved symptoms in patients with irritable bowel syndrome (IBS)…

BACKGROUND: Mast cells are a major actor in the development of abdominal pain, a hallmark symptom of IBS. We recently showed that a local IgE production triggers mast cell activation leading to food-induced abdominal pain in mice…