Detlef Schuppan

BACKGROUND: Irritable bowel syndrome (IBS) is a common disorder with complex pathophysiological mechanisms. Prior studies suggest that 25-50% of patients with diarrhea-predominant IBS (IBS-D) have evidence of bile acid (BA) diarrhea (BAD)…

INTRODUCTION Interleukin-15 (IL-15) is an important cytokine involved in tissue homeostasis and inflammation, and a potent regulator of innate and adaptive immune responses…

Interleukin-15 (IL-15) is a cytokine involved in tissue homeostasis and inflammation, and a potent regulator of innate and adaptive immune responses. IL-15 expression has been shown to be dysregulated in celiac disease (CeD)…

SOCIETY: AGA Genes and dietary gluten are necessary, but insufficient, to develop celiac disease, a common autoimmune enteropathy with systemic manifestations and co-morbid associations. Microbes, in the form of infections and perturbations of the gut microbiome, have emerged as key cofactors…