Ravinder Gill

Reactive oxygen species (ROS) are by-products of normal cellular metabolism with low to moderate amounts being beneficial in several physiological processes in the intestine. Chemotherapy and radiotherapies are largely based upon ROS generation to destroy malignant cells by inducing apoptosis…

BACKGROUND: Diet is known to alter the risk of depression. Increasing data also demonstrate a causal role of the gut microbiome in mental illness, via the gut-brain axis. However, it remains unclear how diet and the microbiome mechanistically influence depression risk in humans…

SOCIETY: AGA Natural products obtained from diet or microbial derived metabolites are increasingly gaining attention for their potential therapeutic potential in gastro-intestinal disorders…

SOCIETY: AGA Solute carrier (SLC) transporters play critical roles in mediating transport of ions, nutrients, neurotransmitters, drugs, across biological membranes…

P-glycoprotein (Pgp), encoded by the MDR1 (multidrug resistance 1/_ABCB1) _gene plays a critical role in maintaining intestinal homeostasis by pumping out xenobiotics/bacterial toxins from the mucosa into the gut lumen…

SOCIETY: AGA

BACKGROUND: Down Regulated in Adenoma (DRA) or SLC26A3 is the key anion transporter involved in chloride absorption in the intestine. _Slc26a3_ polymorphism has been linked to the pathogenesis of IBD, and DRA deficiency is a critical event underlying IBD-associated diarrhea…

Delve into the critical role of epithelial junctions and barrier function in gut health, disease, and therapeutic innovation…