Waddah Alrefai

P-glycoprotein (Pgp), encoded by the MDR1 (multidrug resistance 1/_ABCB1) _gene plays a critical role in maintaining intestinal homeostasis by pumping out xenobiotics/bacterial toxins from the mucosa into the gut lumen…

BACKGROUND: Down Regulated in Adenoma (DRA) or SLC26A3 is the key anion transporter involved in chloride absorption in the intestine. _Slc26a3_ polymorphism has been linked to the pathogenesis of IBD, and DRA deficiency is a critical event underlying IBD-associated diarrhea…