Seema Saksena

BACKGROUND: Diet is known to alter the risk of depression. Increasing data also demonstrate a causal role of the gut microbiome in mental illness, via the gut-brain axis. However, it remains unclear how diet and the microbiome mechanistically influence depression risk in humans…

P-glycoprotein (Pgp), encoded by the MDR1 (multidrug resistance 1/_ABCB1) _gene plays a critical role in maintaining intestinal homeostasis by pumping out xenobiotics/bacterial toxins from the mucosa into the gut lumen…

BACKGROUND: Down Regulated in Adenoma (DRA) or SLC26A3 is the key anion transporter involved in chloride absorption in the intestine. _Slc26a3_ polymorphism has been linked to the pathogenesis of IBD, and DRA deficiency is a critical event underlying IBD-associated diarrhea…