R. Balfour Sartor

The role of nutrition and the microbiome is evident in IBD and functional bowel disorders. The microbiome can affect the way nutrients are metabolized in bioactive components. It is of important to understand the molecular sensors of such metabolized components…

BACKGROUND: Enterochromaffin cells (ECs) are specialized gastrointestinal (GI) epithelial cells that transduce luminal forces and chemicals into release of signal molecules including serotonin (5-HT) to alter GI function including mucosal ion transport…

The microbiome plays a central role in intestinal inflammation in IBD. It is influenced by environmental factors included diet…

BACKGROUND: Emerging evidence suggest that gut microbiota influence human health such as digestive functions and risk of sepsis…

Genetic and environmental influences contribute to Crohn’s disease (CD) development. However, the relationship between these two factors is unclear, limiting insights into CD pathophysiology, as well as interventions to prevent disease…

BACKGROUND: Mucus-digesting _Ruminococcus gnavus _(_Rg_), adherent-invasive _E. coli _(AIEC) and hydrogen sulfide (H2S) are enriched in active Crohn’s disease (CD) compared to healthy subjects…