Sp210
THERAPEUTIC POTENTIAL OF MICROBIOTA DERIVED AHR LIGANDS IN IBD
Date
May 6, 2023
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Society: AGA
The role of nutrition and the microbiome is evident in IBD and functional bowel disorders. The microbiome can affect the way nutrients are metabolized in bioactive components. It is of important to understand the molecular sensors of such metabolized components. Tryptophan is known to mediate Indole derivatives and other molecules that activate a nuclear receptor Aryl Hydrocarbon Receptor. Recently, many advances were made in relating tryptophan and its metabolites to a variety of inflammatory and functional disorders. The session brings together specialists in the field that work on AhR signaling in IBD, IBS, Celiac disease and cancer, to review current strategies to understand tryptophan metabolites and potentially harness nutritional support of disease states.
The role of nutrition and the microbiome is evident in IBD and functional bowel disorders. The microbiome can affect the way nutrients are metabolized in bioactive components. It is of important to understand the molecular sensors of such metabolized components. Tryptophan is known to mediate Indole derivatives and other molecules that activate a nuclear receptor Aryl Hydrocarbon Receptor. Recently, many advances were made in relating tryptophan and its metabolites to a variety of inflammatory and functional disorders. The session brings together specialists in the field that work on AhR signaling in IBD, IBS, Celiac disease and cancer, to review current strategies to understand tryptophan metabolites and potentially harness nutritional support of disease states.
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