Huiping Zhou

BACKGROUND: Emerging evidence suggest that gut microbiota influence human health such as digestive functions and risk of sepsis…

SOCIETY: AASLD

BACKGROUND: Chronic cholestatic liver diseases, such as primary sclerosing cholangitis (PSC), often lead to end-stage liver disease requiring liver transplantation. PSC also significantly increases the risk of cholangiocarcinoma (CCA)…

BACKGROUND: Hepatocellular (_25R_)26-Hydroxycholesterol (26HC) and 3β-Hydroxy-5-cholestenoic acid (3βHCA) accumulations due to chronic oxysterol 7α-hydroxylase (CYP7B1) suppression represent a major driving force for the transition from metabolic dysfunction-associated steatotic liver (MASL) to ste…