Timothy Wang

Introduction: Shifts towards high-fat, low-fiber diets, may contribute to the rising incidence of esophageal adenocarcinoma (EAC). In mice high-fat diet promotes EAC, possibly through effects on the gut microbiome and the systemic bile acid pool…

BACKGROUND: Pancreatic cancer (PC) features highly proliferative cancer cells and a dense stroma modulating tumor growth. Due to the invasive behavior of PC and the lack of effective treatments, there is a pressing need to develop therapies targeted at tumorigenic events to slow down PC progression…

Pyloric metaplasia or spasmolytic polypeptide-expressing metaplasia (SPEM) routinely develops in the setting of oxyntic atrophy, where parietal and chief lineages are lost…

The cholecystokin-2/gastrin receptor (CCK2R) is expressed in corpus isthmus progenitor cells and parietal/ECL cells, and can regulate their homeostatic cellular turnover. While gastrin elevations induce ECL cells expansion from CCK2R+ progenitors (Cell Mol Gastroenterol Hepatol…

Background: Bile acids comprise a major component of refluxate in GERD, the major risk factor for Barrett’s esophagus (BE) and esophageal adenocarcinoma (EAC). Bile acids are metabolized by bacteria, and bacterial composition is also impacted by exposure to bile acids…