Yosuke Ochiai

Pyloric metaplasia or spasmolytic polypeptide-expressing metaplasia (SPEM) routinely develops in the setting of oxyntic atrophy, where parietal and chief lineages are lost…

The cholecystokin-2/gastrin receptor (CCK2R) is expressed in corpus isthmus progenitor cells and parietal/ECL cells, and can regulate their homeostatic cellular turnover. While gastrin elevations induce ECL cells expansion from CCK2R+ progenitors (Cell Mol Gastroenterol Hepatol…