Sven Wehner

The mammalian tissues express a huge number of circular RNAs (circRNAs) with an active role in gene regulation. circRNAs are covalently closed at the 5’ and 3’ ends, unusually stable, and are highly distributed in the cytoplasm…

BACKGROUND: Perianal fistulae are highly morbid complications of Crohn’s disease (CD) with a cumulative incidence of 20-25%; despite demonstrated efficacy of infliximab treatment, estimates of complete resolution are only 20-30%. Ultimately, 20% of patients will require proctectomy…

Background: Postoperative ileus (POI) is a common consequence of abdominal surgery and a neuroinflammation-based disorder of the gastrointestinal tract, which results in motility disturbances compromising patients' recovery…

The wiring of the enteric nervous system (ENS) is a dynamic process throughout development and adulthood. In the embryo, enteric neural crest derived cells expand and differentiate into the glia and neurons that form the ENS…

_BACKGROUND:_ Current studies provide compelling evidence that the enteric nervous system (ENS), together with immune cells, modulate neuroimmune processes in the gut. Previous work revealed the essential role of resident macrophages (Macs) therein…