Fievos Christofi

The wiring of the enteric nervous system (ENS) is a dynamic process throughout development and adulthood. In the embryo, enteric neural crest derived cells expand and differentiate into the glia and neurons that form the ENS…

BACKGROUND: Perianal fistulae are highly morbid complications of Crohn’s disease (CD) with a cumulative incidence of 20-25%; despite demonstrated efficacy of infliximab treatment, estimates of complete resolution are only 20-30%. Ultimately, 20% of patients will require proctectomy…

SOCIETY: AGA Showcasing recent data from leading groups, this session will overview the roles of the mechanosensory ion channel PIEZO2 in the control of gastrointestinal motility, nociception, and hypersensitivity associated with inflammatory and functional gastrointestinal disorders and the cell t…