Ajay Goel

The epigenome is the heritable portion of the genome that is mediated by chemical modification of DNA (methylation) or nuclear proteins (histones, transcription factors) without changing the DNA sequence…

BACKGROUND: Alcohol-associated hepatitis (AH) is the active inflammatory state of alcohol-associated liver disease (ALD). AH varies in severity from mild to severe with mortality rates reaching 30-50% in severe AH…

Background: Esophageal cancer incidence and mortality are projected to increase by 58.4% and 61.8% by the end of 2040, making esophageal squamous cell carcinoma (ESCC) – the most common subtype a significant public health threat…

SOCIETY: AGA Aging is associated with increased GI cancer risk but the mechanisms underlying these age related effects are incompletely understood. Better understanding of mechanisms of aging and GI carcinogenesis will enable new approaches to early detection and prevention…

Background: Tumor recurrence is the event that has a major impact on survival after local resection of submucosal colorectal cancers (T1 CRC). However, currently, there are no established biomarkers to predict disease-free survival (DFS) in T1 CRC…

INTRODUCTION: Patients with early-onset colorectal cancer (EOCRC), defined as diagnosed before age 50, have a significant risk of metachronous CRC after curative resection. The practice of offering intensive endoscopic surveillance, although often used, has not been formally validated…

SOCIETY: AGA Join this session to review current and future applications for AI in assessing GI cancer risk, and guiding cancer screening and cancer therapeutics in research and clinical care settings…

Uncover the genetic and molecular foundations of GI disorders to drive precision medicine and innovative therapies…