Microbiome in Gastrointestinal and Liver Diseases

Infectious diarrhea is a leading cause of morbidity and of mortality globally. Enteric pathogens that are the cause of most severe acute diarrhea — as assessed by mortality — include Vibrio cholerae, Shigella spp., Salmonella spp., enteropathogenic E. coli(EPEC), and EAEC…

Reactive oxygen species (ROS) are by-products of normal cellular metabolism with low to moderate amounts being beneficial in several physiological processes in the intestine. Chemotherapy and radiotherapies are largely based upon ROS generation to destroy malignant cells by inducing apoptosis…

Visceral pain is a leading cause of disability worldwide, affecting 20% of the population. Increased sensitivity to normal innocuous stimuli in the intestine is a hallmark of many organic and functional gastrointestinal disorders…

Understand drug metabolism and disposition is critical to reduce patient morbidity and mortality. Explore the interplay between bacteria and the intestinal microenvironment unveils new knowledge of host-associated microbial communities that play a key role in the control drug metabolism…

The gut microbiome is implicated in a wide range of physiological processes, and holds great, but unrealized, potential for disease treatment and prevention…

40 years after the organism was first recognized and grown in culture, Helicobacter pylori infections are still commonly encountered in practice,. This symposium will focus on several areas that remain unresolved to this day - including how best to manage H…

Microbiome science in the gut has focused on the study of colonic, and more frequently, fecal communities. While the upper gastrointestinal tract has significantly lower bacterial density than the colon, it still harbors a dynamic microbial community…

The role of nutrition and the microbiome is evident in IBD and functional bowel disorders. The microbiome can affect the way nutrients are metabolized in bioactive components. It is of important to understand the molecular sensors of such metabolized components…

SOCIETY: AGA

This session highlights thecurrent FDA approved microbiome therapeutics and their applications and the exciting avenues being pursued for the next generation of microbiome therapeutics using gene editing and synthetic microbial communities…

The gastrointestinal tract is a diverse and complex ecosystem shaped by continual interactions between host cells, nutrients, and the gut microbiota. Under homeostatic conditions, the human gut microbiota limits the growth of pathogenic bacteria and restricts the influence of resident pathobionts…

Through the history of gut microbiome research, basic, translational, and clinical studies revealed many critical roles played by gut-resident bacteria in affecting human health and disease…

The molecular circadian clock helps optimize host physiology to the environment by influencing the timing and coordination of metabolic processes. Host-microbe interactions also play an important role in determining metabolic responses to environmental challenges…

SOCIETY: AGA

SOCIETY: DDW

A session focusing on recent advances in our understanding of the complex pathophysiology of disorders of gut-brain interaction (DGBI)…

In this session, you will learn about the advances in microbial biotransformation of drugs and this can impact clinical outcomes and adverse events…

In this session we will learn about the exciting advances in mechanisms by which microbial metabolites as well can drive metabolic disorders and the pipeline of potential microbial therapeutics to treat metabolic disorders…

SOCIETY: AASLD

This session was jointly developed by AGA and representatives from the Division of Gastroenterology at the FDA Center for Drug Evaluation and Research…

The microbiome plays a central role in intestinal inflammation in IBD. It is influenced by environmental factors included diet…

This session will cover the pathogenic and non-pathogenic constituents of the gut microbiome that induce local and systemic inflammatory response and play an important role in disease development…

SOCIETY: AGA

SOCIETY: AGA