John E. Pandolfino

This session will have six talks on the indications, limitations, procedural and technical aspects on clinically useful GI physiology tests. The attendees will learn for which patients these test can be of value, and what type of results you can expect and how reliable these are…

BACKGROUND: There is a lack of data on training benchmarks to define competence in colorectal EMR (C-EMR) among advanced endoscopy trainees (AETs). Previous pilot data from our group demonstrated a relatively low proportion of AETs achieve competence on key cognitive and technical aspects of C-EMR…

BACKGROUND: Video analysis has emerged as a potentially strategy for performance assessment of specialized techniques where local expertise and mentorship are limited…

Background: Eosinophilic Esophagitis (EoE) is one of the most predominant causes of chronic esophageal symptoms in children. Pathological changes of the esophageal epithelium in EoE are characterized by basal cell hyperplasia (BCH), infiltration of eosinophils and elevated levels of cytokines (e.g…

As many as 30-50% of the patients referred to the tertiary care center with dysphagia symptoms have normal endoscopy, barium esophagram, and high-resolution manometry and are classified as functional dysphagia.The reason for their symptoms remains unknown and management is challenging…

Concomitant esophageal dysmotility can be present in up to 2/3 of patients with EoE and GERD. Esophageal dysmotility contribute to symptoms in these patients and can be a reason for a suboptimal response to therapy…

BACKGROUND: Novel treatment options for eosinophilic esophagitis (EoE) are needed. Previous studies have assessed mepolizumab (mepo), a monoclonal antibody against IL-5, with mixed results in EoE, and the efficacy of mepo in an adult and adolescent population has yet to be fully examined…

INTRODUCTION: Colonoscopy reduces colorectal cancer mortality via the identification and removal of neoplastic polyps. In clinical trials, computer aided detection (CADe) improves polyp detection, but there is limited data of CADe implementation in routine practice…

Dysphagia and chest pain are the common symptoms in achalasia. The mechanisms underlying such symptoms are not completely understood. The two symptoms can be triggered by mechanical stimulation via the sensory vagal and spinal afferent nerve fibers…

INTRODUCTION: A number of medications have been implicated as primary risk factors for microscopic colitis (MC) and guidelines recommend discontinuation of these medications as part of MC management…

BACKGROUND AND AIM: Despite extensive cleaning and disinfection protocols, 5-15% of ready-to-use duodenoscopes are still contaminated with high concern (HC) microorganisms such as _Klebsiella pneumoniae_, _Escherichia coli_ and _Pseudomonas aeruginosa_…

BACKGROUND: The Lyon Consensus 2.0 identifies physiologic, borderline and pathologic reflux burden from acid exposure time (AET), reflux episodes (RE), and mean nocturnal baseline impedance (MNBI)…

The objective measurement for esophageal bolus volume will classify abnormal high-resolution manometry (HRM) beyond the current Chicago classification…

BACKGROUND: A scheme for classifying esophageal motility using Functional Lumen Imaging Probe (FLIP) Panometry that paralleled high-resolution manometry (HRM) was previously developed and described in a study of 722 subjects…

Despite high success rates of per-oral endoscopic myotomy (POEM) in treatment of achalasia, many patients continue to experience symptoms. Utilization of functional luminal imaging probe (FLIP) during POEM has allowed for real-time assessment of myotomy adequacy…

The diagnosis of GERD is being updated using the Lyon Consensus 2.0 (updated in 2023), which takes into account a modern diagnosis of GERD, symptoms of GERD, optimal testing as well as metrics and thresholds used to diagnose conclusive GERD…