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Sp906
WELCOME AND INTRODUCTION OF LECTURESHIP AND LECTURER
Date
May 8, 2023
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Increasing scientific evidence supports the key role of brain-gut interactions in chronic gastrointestinal (GI) disorders such as irritable bowel syndrome (IBS). IBS and other functional GI disorders have been redefined as disorders of gut-brain interaction (DGBI) which is associated with alterations in visceral sensitivity, gut motility and secretion, immune function, gut microbiome and/or central nervous system processing of visceral events. Bidirectional communication between the brain and gut (including the microbiome) occurs via neural, immune, and hormonal pathways. The brain-gut axis can be significantly impacted both centrally (e.g., stressful life events, psychological symptoms) and peripherally (e.g., infection, food) leading to the onset or exacerbation of IBS. Understanding the clinical presentation and the pathophysiology of IBS allows us to apply our knowledge to enhancing effective patient care and developing novel diagnostic and therapeutic approaches.
LIVE STREAM SESSION
Abdominal pain is one of the most common reasons for doctors visits, and presents in numerous GI diseases. Unfortunately the current treatment options targeting sensory neurons to reduce pain have limited efficacy or unwanted side effects, and this is especially true for visceral pain…
Switching from originator to biosimilar infliximab (IFX) is effective and safe. However, data on multiple switching are scarce. The Edinburgh IBD unit has undertaken three switch programmes: (1) Remicade to CT-P13 (2016), (2) CT-P13 to SB2 (2020), and (3) SB2 to CT-P13 (2021)…
Perturbations in the gut mucosal immune response contributes to IBD. Non-immune cell popopulations including epithelial and stromal cells also play an important role in intestinal inflammation…
Increasing scientific evidence supports the key role of brain-gut interactions in chronic gastrointestinal (GI) disorders such as irritable bowel syndrome (IBS)…