AGA Morton I. Grossman Distinguished Lectureship — Brain-Gut Interactions in IBS: Novel Applications for Clinical Practice

Society: AGA

Increasing scientific evidence supports the key role of brain-gut interactions in chronic gastrointestinal (GI) disorders such as irritable bowel syndrome (IBS). IBS and other functional GI disorders have been redefined as disorders of gut-brain interaction (DGBI) which is associated with alterations in visceral sensitivity, gut motility and secretion, immune function, gut microbiome and/or central nervous system processing of visceral events. Bidirectional communication between the brain and gut (including the microbiome) occurs via neural, immune, and hormonal pathways. The brain-gut axis can be significantly impacted both centrally (e.g., stressful life events, psychological symptoms) and peripherally (e.g., infection, food) leading to the onset or exacerbation of IBS. Understanding the clinical presentation and the pathophysiology of IBS allows us to apply our knowledge to enhancing effective patient care and developing novel diagnostic and therapeutic approaches. LIVE STREAM SESSION