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Sp736
THE ROLE OF FIBROBLASTS IN FIBROSTENOSING CROHN'S DISEASE
Date
May 20, 2024
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BACKGROUND: Inflammatory bowel disease (IBD)-associated intestinal fibrosis is a significant clinical problem. Excessive accumulation of extracellular matrix (ECM) derived from intestinal myofibroblasts (HIMF) is a hallmark of intestinal strictures…
_INTRODUCTION:_ Despite effective anti-inflammatory therapies, ~70% of CD patients require surgery in their lifetime, due to fibrostenotic strictures linked to excess extracellular matrix (ECM) deposition…