The accreditors of this session require that you periodically check in to verify that you are still attentive. Please click the button below to indicate that you are.
RECLASSIFYING CONSTIPATION USING COLONIC VOLUME ASSESSED BY MRI, WHOLE GUT TRANSIT, PSYCHOLOGICAL DISTRESS AND PAIN SCORES
Objectives: This study was designed to investigate the effects of TEA on postoperative recovery and possible mechanisms involving autonomic functions.
Materials and Methods: A total of 81 TVF patients who underwent elective posterior pedicle screw fixation surgery were randomized to receive TEA or sham-TEA. After enrollment, electrocardiogram (ECG) was recorded for 30 min to assess autonomic function. TEA at ST36 or sham-TEA at non-acupoints was performed for one hour twice daily from 24 hours before surgery to postoperative day (POD) 3. Clinical symptoms were assessed in the form of diary. In the morning of POD1 and POD4, the ECG was recorded again for 30 min .
Results: 1) In comparison with sham-TEA, TEA enhanced postoperative recovery associated with lower GI motility (see Fig.1), including a reduction in time to defecation by 27.2% (P =0.002), time to first flatus by 17.2% (P = 0.027), an increase in the Bristol stool score (P = 0.014) and the number of spontaneous bowel movement (SBM,P =0.009). 2) TEA also improved other GI symptoms including abdominal bloating on POD1 and POD4 (P < 0.001 and P=0.001, respectively), straining during defecation (P<0.001) and sensation of anorectal blockage during defecation (P=0.02) in comparison with sham-TEA. 3) TEA reduced the visual analogue scale (VAS) wound pain score on POD1 (P=0.026), POD2 (P< 0.001) and POD3 (P< 0.001). 4) TEA but not sham-TEA increased vagal activity and decreased sympathetic activity (P < 0.001) on POD4 compared with POD1, assessed from the spectral analysis of heart rate variability derived from the ECG. The serum level of norepinephrine (NE) was significantly lower in the TEA group in comparison with the sham-TEA group on both POD1 (P=0.047) and POD4 (P=0.036). 5) The use of TEA was found to be an independent predictor of shortened time to first defecation.
Conclusions: Non-invasive TEA at ST36 is effective in promoting postoperative recovery in TVF patients by enhancing vagal and suppressing sympathetic activities.

Methods: 25 patients (age 52±14 years, 76% male) with SCI (>1 year) above T12 with chronic constipation underwent WMC testing. Patients on opioids were excluded. Stimulant laxatives and GI motility drugs were stopped 48 hours before testing. Rescue suppository laxatives were permitted at day 7. WMC transit parameters included gastric emptying time (GET)(delayed >5 hours), SB transit time (SBTT)(delayed>6 hours), and colon transit time (CTT)(delayed>59 hours). Motility parameters included contractions per minute and motility index or MI (ln) 30 min prior to WMC pylorus passage (gastric), 30 min after pylorus passage (proximal SB), 30 min before ileocecal junction (ICJ) passage (distal SB), 30 min after ICJ passage (proximal colon), and 30 min before anal expulsion (distal colon).
Results: SCI level was cervical in 17 (68%) and thoracic in 8 (32%) patients; time since SCI was <10 years in 16 (64%) and >10 years in 9 (36%) patients. Transit delays in the stomach, SB, and colon were prevalent and were similar with cervical vs. thoracic SCI (Figure). Transit delays <10 vs. >10 years after SCI were not different for GET (18.8 vs. 44.4%, P=0.35), SBTT (37.5 vs. 44.0%, P=1.00), or CTT (50.0 vs. 33.3%, P=0.66). Proximal SB contraction frequency (P=0.02) and MI (P=0.03) were lower after cervical vs. thoracic SCI, but contraction parameters in other gut regions did not differ in relation to level of injury (Table). Contraction frequencies and MI were similar <10 vs. >10 years across all gut regions (data not shown).
Conclusion: Whole gut transit delays involving the stomach, small bowel, and colon are common after spinal injury. These delays were not secondary to medication effects as opioid use was excluded and drugs with motility actions were discontinued before testing. There was no relation of level of spinal injury to transit delay and minimal impact on small bowel contractility, reinforcing the importance of vigilant attention to bowel regimens in all patients. The stability of GI transit delays and contraction profiles over many years suggests such vigilance may need to be lifelong.

Transit delays in the stomach (GET), small bowel (SBTT), and colon (CTT) are common with both cervical and thoracic SCI.

Proximal small bowel (SB) contractile parameters were reduced for cervical vs. thoracic spine injury but were similar between SCI level for other GI regions.

Table 1 Demographics, MRI and questionnaire results showing overlap of IBS-C and FC with both groups distinct from HVs

Table 2 New cluster analysis showing characteristics of the 3 Groups with differences in motility despite similar bowel and stool pattern
Speakers

