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Sp334
MICROBIALLY DERIVED PROTEASES FOR THE TREATMENT OF CELIAC DISEASE
SOCIETY: AGA Genes and dietary gluten are necessary, but insufficient, to develop celiac disease, a common autoimmune enteropathy with systemic manifestations and co-morbid associations. Microbes, in the form of infections and perturbations of the gut microbiome, have emerged as key cofactors…
Interleukin-15 (IL-15) is a cytokine involved in tissue homeostasis and inflammation, and a potent regulator of innate and adaptive immune responses. IL-15 expression has been shown to be dysregulated in celiac disease (CeD)…
BACKGROUND: Recent studies suggest links between _Clostridioides difficile_ infection (CDI) and liver disorders, with non-alcoholic fatty liver disease (NAFLD) increasing CDI risk and CDI exacerbating the progression and prognosis of liver cirrhosis. Moreover, gut dysbiosis, often leading to _C…