AGA Charles M. Mansbach II, MD, Memorial Lecture — When We Eat: How Much Does It Matter?

Society: AGA

The molecular circadian clock helps optimize host physiology to the environment by influencing the timing and coordination of metabolic processes. Host-microbe interactions also play an important role in determining metabolic responses to environmental challenges. The gut microbiome helps break down diet-derived nutrients indigestible by the host, thereby generating metabolites that influence host metabolism and immune function. Host-microbe interactions can be influenced by dietary quality and timing, as well as daily light/dark cycles that entrain circadian rhythms in the host. Together, the gut microbiome and the circadian clock play a coordinated role in determining host metabolism and response to environmental stimuli. In this session, you will learn about the bidirectional interactions between the circadian clock, gut microbiota, and host metabolic systems and their effects on energy homeostasis, obesity and immune dysfunction.