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EXPOSURE TO AN INFLAMMATORY PRENATAL ENVIRONMENT AND THE RISK OF INFLAMMATORY BOWEL DISEASE IN THE OFFSPRING: A POPULATION-BASED COHORT STUDY
The strongest independent risk factor for developing inflammatory bowel disease (IBD) is a family history with IBD. The early life, including the intra-uterine period, is critical for immune system maturation and therefore, exposures during early life can influence IBD risk…
PRE-DIAGNOSTIC BIOMARKERS AND IBD PREDICTION
The burden of IBD is rising globally. This session aims to understand the role of genetics in the development of IBD in diverse populations and define the pre-disease state in IBD. It will also explore the emerging field of multi-omics to clinically characterize IBD…
ANTI-INTEGRIN αVβ6 AUTOANTIBODIES ARE A NOVEL PREDICTIVE BIOMARKER IN ULCERATIVE COLITIS
Aconitate decarboxylase 1 (ACOD1; also known as IRG-1) is the ubiquitous source of the metabolite itaconate, which dampens inflammasome activation by preventing HIF1α production of IL-1β and prevents TNF production through NRF2 activation…