New Knowledge and Pragmatic Guidance from Existing IBD Research: A Cochrane Symposia Demonstrating the Pitfalls and Promise of Network Meta-analyses to Inform Clinical Practice

SOCIETY: AGA Clinical guidelines increasingly rely on technical reviews of evidence and these in turn are becoming increasingly complex in methods. This offers great promise to truly achieve evidence based clinical guidelines. Network Meta-analysis allows studies to be compared not just directly through pairwise analysis, but indirectly accross the network enhancing the precision and conssitency of the evidence and the resulting 'ranking' can appear to offer great promise to guiding clinical decision making. In this session, we will consdier three clinical scenarios of inducing and maintaing remission in Crohn's disease, Ulcerative Colitis and Fistulating disease. We will then exemplify the promise of this form of analysis when completed correctly and including GRADE analysis of the network with the presentation of novel graphical summaries. We will also detail the pitfalls of poor methodology and intepretation.We will use the exemplar of the update to the UK BSG guidelines to demonstrate the impact such findings can have of clinical practice guidelines.