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GLUTEN DEPENDENT ACTIVATION OF CD4+ T CELLS BY MHC CLASS II EXPRESSING INTESTINAL EPITHELIAL CELLS
BACKGROUND AND AIM: Intestinal epithelial cells (IECs) are emerging as potential regulators of CD4+ T cell responses through MHC class II expression. However, their role as antigen-presenting cells and in the activation of gluten-reactive CD4+ T cells has never been proven…
CLOSTRIDIOIDES DIFFICILE INFECTION INDUCES A PRO-STEATOTIC AND PRO-INFLAMMATORY METABOLIC STATE IN LIVER
BACKGROUND: Recent studies suggest links between _Clostridioides difficile_ infection (CDI) and liver disorders, with non-alcoholic fatty liver disease (NAFLD) increasing CDI risk and CDI exacerbating the progression and prognosis of liver cirrhosis. Moreover, gut dysbiosis, often leading to _C…
