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Sp1207
MITOCHONDRIAL DYSFUNCTIONS AS DRIVERS OF EPITHELIAL INJURY IN CHRONIC INFLAMMATION
Date
May 9, 2023
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This session will feature speakers who will examine the mechanisms of inflammation and epithelial tissue repair during mucosal inflammation. Signaling pathways active in epithelial cells to modulate repair as well as epithelial cell mitochondrial dysfunction and its contribution to epithelial injury during chronic inflammation will be discussed.The contribution of stromal fibroblasts to matrix remodeling and would healing will be addressed.
Perturbations in the gut mucosal immune response contributes to IBD. Non-immune cell popopulations including epithelial and stromal cells also play an important role in intestinal inflammation…
Reactive oxygen species (ROS) are by-products of normal cellular metabolism with low to moderate amounts being beneficial in several physiological processes in the intestine. Chemotherapy and radiotherapies are largely based upon ROS generation to destroy malignant cells by inducing apoptosis…
Switching from originator to biosimilar infliximab (IFX) is effective and safe. However, data on multiple switching are scarce. The Edinburgh IBD unit has undertaken three switch programmes: (1) Remicade to CT-P13 (2016), (2) CT-P13 to SB2 (2020), and (3) SB2 to CT-P13 (2021)…