Functional Obstruction in EGIDs: Mechanics to Molecular Mechanisms

Society: AGA

Common presenting symptoms including dysphagia, chest pain, and food impaction are thought to be mediated by inflammatory or fibrotic-associated events in the esophagus. However recent evidence supports a role for esophageal dysmotility in the histologic, endoscopic, and clinical activity in EoE. The major inflammatory components that drive the immunopathogenesis of EoE, mast cells and eosinophils regulate visceral motility and function in the esophagus. This session will feature speakers who will describe esophageal motor abnormalities in EoE, define techniques for assessment, manometric characteristics, and clinical implications of dysmotility in patients with EoE and discuss the mechanisms through which inflammatory cells and mediators modulate esophageal dysmotility.