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Sp394
BILE ACID SIGNALING IN THE TREATMENT OF OBESITY
Date
May 7, 2023
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Enteroendocrine cells play a major role in sensing the luminal contents of the gut and communicating with other organs such as the pancreas, liver and brain. The gut-brain connection is essential in the regulation of food intake. These interaction is neuro-hormonal and mediated by incretin hormones such as GLP-1. Recently, GLP-1 receptor analogs were FDA-approved for obesity and diabetes.
Switching from originator to biosimilar infliximab (IFX) is effective and safe. However, data on multiple switching are scarce. The Edinburgh IBD unit has undertaken three switch programmes: (1) Remicade to CT-P13 (2016), (2) CT-P13 to SB2 (2020), and (3) SB2 to CT-P13 (2021)…
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