Advancing-microbially Based Therapies for Celiac Disease and Other Food Sensitivities

SOCIETY: AGA Genes and dietary gluten are necessary, but insufficient, to develop celiac disease, a common autoimmune enteropathy with systemic manifestations and co-morbid associations. Microbes, in the form of infections and perturbations of the gut microbiome, have emerged as key cofactors. In this translational symposium the basic immune and metabolic mechanisms by which microbial cofactors modulate celiac disease risk will be discussed, as well as how this insight is being translated into microbially-directed therapies.

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