AASLD
- DateMay 18, 2024
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Richmond VA Medical Center - DateMay 18, 2024
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Atrium Health - DateMay 18, 2024ADDICTION TREATMENT AND HARM REDUCTION IN VIRAL HEPATITIS
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The University of Texas Southwestern Medical CenterPinnacle Clinical ResearchSpeakers
- DateMay 18, 2024Background and Objective: Biliary senescence in primary biliary cholangitis (PBC) patients is positively correlated with disease severity, prognosis, and poor UDCA response…
- DateMay 18, 2024BACKGROUND: Approximately 40% of primary biliary cholangitis (PBC) patients exhibit poor response to ursodeoxycholic acid (UDCA) and prognosis, referred to as refractory PBC. There is an urgent need to explore new treatment approaches for this patient population…
- DateMay 18, 2024_BACKGROUND:_ Primary Biliary Cholangitis (PBC) is a cholestatic liver disease characterized by chronic inflammation and granulomatous destruction of interlobular bile ducts…
- DateMay 18, 2024Background: Primary sclerosing cholangitis (PSC) is a progressive choleostatic disease and up to 80% of patients also have ulcerative colitis (PSC-UC). This presents a clinical challenge owing to difficulty in diagnosis and increased risk for developing cancer…
- DateMay 18, 2024INTRODUCTION: Transient elastography (TE) is a noninvasive alternative to biopsy for assessment of liver stiffness and indirectly fibrosis, which can be predictive of adverse outcomes in patients with primary biliary cholangitis (PBC)…
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University of Nevada Las Vegas School of Medicine - DateMay 18, 2024INTRODUCTION: Obeticholic acid (OCA), a potent farnesoid X receptor agonist, is indicated as a second-line treatment for patients (pts) with primary biliary cholangitis (PBC) who have an inadequate response or intolerance to ursodeoxycholic acid…
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- DateMay 18, 2024METABOLIC OUTCOMES AND KEY EFFICACY DATA FROM A PHASE 2 TRIAL EVALUATING COMBINATION OBETICHOLIC ACID AND BEZAFIBRATE IN PATIENTS WITH PRIMARY BILIARY CHOLANGITIS
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Indiana UniversityUniversity of Southern CaliforniaSpeakers
University of Nevada Las Vegas School of Medicine - DateMay 18, 2024Background: Primary Sclerosing Cholangitis (PSC), a chronic liver disease, is often intertwined with Inflammatory Bowel Disease (IBD), presenting a complex clinical scenario. The coexistence of IBD-PSC complicates disease management and progression, potentially exacerbating outcomes…
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Rochester Regional Health - DateMay 18, 2024BACKGROUND: The incidence and prevalence of cirrhosis and overt hepatic encephalopathy (OHE), a serious complication of cirrhosis associated with recurrent and expensive hospitalizations, have increased over time…
- DateMay 18, 2024BACKGROUND: While sodium-glucose cotransporter 2 inhibitors improves cardiovascular and renal outcomes irrespective of diabetes mellitus (DM) status, their effects in metabolic-dysfunction associated steatotic liver disease (MASLD) patients without diabetes mellitus (DM) are unknown…
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University of Hong Kong Li Ka Shing Faculty of Medicine - DateMay 18, 2024Metabolic dysfunction-associated steatotic liver disease (MASLD) is highly prevalent and a leading cause of liver-related morbidity and mortality…
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Massachusetts General HospitalMassachusetts General Hospital - DateMay 18, 2024BACKGROUND: Seladelpar, a potent and selective PPAR-delta agonist, has anti-cholestatic and anti-pruritic activity in patients with primary biliary cholangitis (PBC)…
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University of Miami - DateMay 18, 2024BACKGROUND: Patients with MASLD and diabetes have an increased risk of cirrhosis and hepatocellular cancer (HCC). Recent studies show that glucagon-like peptide-1 (GLP-1) agonists, such as semaglutide, are effective in improving liver inflammation in MASLD…
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Michael E. DeBakey VAMCSpeakers
The Perelman School of Medicine at the University of PennsylvaniaBaylor College of Medicine - DateMay 18, 2024ASSOCIATION OF GLUCAGON-LIKE PEPTIDE-1 AGONISTS WITH CIRRHOSIS AND HEPATOCELLULAR CANCER IN METABOLIC DYSFUNCTION ASSOCIATED STEATOTIC LIVER DISEASE (MASLD)
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Stanford UniversityDuke UniversitySpeakers
Michael E. DeBakey VAMCUniversity of Miami FECAL EXTRACELLULAR VESICLES FROM ALD SUBJECTS EXACERBATED ALCOHOL-ASSCOCIATED LIVER DISEASE IN MICE
DateMay 20, 2024_OBJECTIVES_: Fecal microbiota transplantation (FMT) is a novel therapeutic strategy for alcohol-associated liver disease (ALD). However, adverse effects have been reported due to possible pathogenic bacteria colonization…Speakers
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- DateMay 20, 2024BACKGROUND AND AIMS: Alcoholic liver disease (ALD) is one of the most prevalent chronic liver diseases and an increasing healthcare burden worldwide. The aim of this study was to investigate the effects of dietary fiber and gut microbiota on ALD and to explore the molecular regulatory mechanisms…
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- DateMay 20, 2024BACKGROUND: People with alcohol use disorder (AUD) often suffer from multiple tissue injuries. Cytochrome P450-2E1 (CYP2E1) is the ethanol (EtOH)-inducible enzyme present in many organs and can generate oxidative stress and lipid peroxides…
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